Smirnov George

Smirnov George, Professor of Molecular Biology
Smirnov George, Professor of Molecular Biology

phone: 8-926-219-6670

Scientific interests and the field of research
Microbial molecular genetics, genetics and molecular biology of pathogenic bacteria, mechanisms of the genomes’ evolution.
Selected works

1. G. B. Smirnov and A. G. Skavronskaya. Location of uvr502 mutation of the chromosome of Escherichia coli K-12 . Molecular and General Genetics MGG 1971, Volume 113, Number 3, 217-221.
2. G.B.Smirnov, Yu.N.Favorskaya, A.G.Skavronskaya. Monofunctional Alkylating Agent-Induced Inactivation, Mutagenesis and DNA Degradation in in an Escherichia coli Mutant Deficient in DNA Polymerase. Molec.Gen. Genetics, 111, 1971, p.357-367.
3. B.I.Sinzinis, G.B.Smirnov, A.S.Saenko. Effect of polA1 mutation on the ability of Escherichia coli K 12 to repair single strand breaks of DNA induced by methylmethanesulfonate. Biochimica et Biophysica Acta, 247, 1971, p.635-639.
4. G.B.Smirnov, E.V.Filkova, A.G.Skavronskaya. Loss and Restoration of Viability of E.coli Due to Combonations of Mutations Affecting DNA Polymerase I and Repair Activities. Molec. gen. Genet. 121, 1973 p.139-150.
5. B.I.Sinzinis, G.B.Smirnov, A.A.Saenko. Repair Deficiency in Escherichia coli UV-sensitive Mutator Strain uvr502. Biochem. Biophys. Res.Communs. 53,1,1973, p.309-316.
6. G.B.Smirnov, A.G.Skavronskaya. Suprssion of Ultraviolet Sensitivity in Escherichia coli uvr502 by the su58 Missense Suppressor. Journal of Bacteriology, v.115, No.2 1973, p.486-489.
7. G.B.Smirnov, E.V.Filkova, A.G.Skavronskaya. Base Pair Substitutions Caused by the uvr502 Mutation Affecting Mutation Rates and UV-Sensitivity of Escherichia coli. Molec. gen. Genet. 126, 1973, p.255-266
8. A.G.Skavronskaya, G.B.Smirnov. Reversions of the two missense and one nonsense trpA mutations induced by UV-light or methyl methanesulfonate in E.coli wild type and its polA1 and uvrE502 Mutants. Mutation Research, 28, 1975, p.311-322.
9. G.B.Smirnov, B.I.Sinzinis, A.S.Saenko. The role of DNA polymerase I in genetic Recombination and Viability of Escherichia coli. Molecular Mechanisms for Repair of DNA, Part A, Plenum Press, New York, 1975, p.399-404.
10. A.S.Saenko, B.I.Sinzinis, G.B.Smirnov. Disturbance of the high polymeric DNA formation in the double mutant E.coli cells. Proc. A.S. USSR. 1974. - v. 214. – No. 2. - pp. 451-455 (in Russian).
11. A.S.Saenko, B.I.Sinzinis, G.B.Smirnov. Formation of the double stranded DNA breaks in the course of its replication. Radiocytology -75. Leningrad , 1976. - P. 34(in Russian).
12. G.B.Smirnov, T.S.Ilyna, Y.M.Romanova, A.P.Markov, E.V.Nechaeva. Mutants of Escherichia coli Affected in the Processes of Transposition and Genomic Rearragements. Cold Spring Harbor Sym. Quant.Biol. v.45, 1981, p.193-199.
13. T.S.Ilyina, E.V.Nechaeva, Yu.M.Romanova, G.B.Smirnov. Isolation and mapping of Escherichia coli K12 mutants defective in Tn9 transposition. Mol.Gen. Genet. 181 1981, p.384-389.
14. Ginzburg A.L., Yanishevsky N.V., G.B.Smirnov. Cloning and expression of determinants, encoding toxigenicity in enterobacteria. Gene manipulation and expression Ed.K-E Glass, Prague, 1985, а.25-30.
15. N.I.Smirnova, T.S.Ilyna, G.A.Eroshenko, G.B.Smirnov. Construction of donor strains of classical and EL-Tor biotypes of Vibrio cholerae using R-plasmids and genetic mapping of the V.cholerae chromosome. J.Diarr. Dis. Res. 5 (1) p.16-23, 1987.
16. G.B.Smirnov. Molecular biology of the factors responsible for Yersinia virulence. Biomedical Science 1990, v.1, а.223-232.
17. V.L.Motin, M.S.Pokrovskaya, M.V.Telepnev, V.V. Kutyrev, N.A.Vidyaeva, A.A.Filippov, G.B. Smirnov. The difference in the lcrV sequences between Y.pestis and Y.pseudotuberculosis and its application for characterization of Y.pseudotuberculosis strains. Microbial Pathogenesis 1992; 12, 165-175.
18. G.B.Smirnov, F.N.Shubin, A.L.Ginzburg, G.Shovadaeva, I.A.Shaginyan, T.S.Iliyna, A.P.Markov, M.S.Pokrovskaya, I.S.Sever, N.S.Barteneva, L.V.Volkov. Molecular biology of Yersinia pseudotuberculosis large plasmid pVM82. Current Investigations Microbiology of Yersiniae. Editors: T.Une, T.Maruyama M.Tsubokura. Contributions to Microbiology and Immunology. 1991, p.210-212.
19. V.L.Motin, R.Nakajima, G.B.Smirnov, R.R.Brubaker. Passive Immunity to Yersiniae Mediated by Anti Recombinant V Antigen and Protein A-V Antigen Fusion Peptide. Infection and Immunity, 1994, vol. 62, 10, 4192-4201.
20. T.S.Ilyina, S.L.Filkova, M.S.Pokrovskaya, G.B.Smirnov. Genetic studies of Yersinia pseudotuberculosis plasmid pVM82. 6th International symposium on Yersinia. ( Abstracts ) Rome, Italy,1994, p.79.
21. V.V.Kutyrev, V.L.Motin, O.A.Protsenko, G.B.Smirnov, R.R.Brubaker. Active protection of mice from plague with a fusion protein containing V antigen of Yersinia pseudotuberculosis. 6th International symposium on Yersinia. (Abstracts ) Rome, Italy,1994, p.95.
22. Abramov VM, Khlebnikov VS, Vasiliev AM, Kosarev IV, Vasilenko RN, Kulikova NL, Khodyakova AV, Evstigneev VI, Uversky VN, Motin VL, Smirnov GB, Brubaker RR. Attachment of LcrV from Yersinia pestis at dual binding sites to human TLR-2 and human IFN-gamma receptor.
J Proteome Res. 2007 Jun;6(6):2222-31. Epub 2007 Apr 19.
23. Smirnov George B. Reduction and possible mechanisms of evolution of the bacterial genomes. In: National Institute of Allergy and Infectious Diseases, NIH, Vol.1 Frontiers of Research. V.S. Georgiev et al. eds. Humana Press, 2008. pp. 205-214.