Lab of Molecular Genetics of Microorganisms

Meet our team

Meet our team

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Egor Shitikov, PhD, Head of the laboratory

George SMIRNOV, DSc., Professor, Chief Scientific Officer

Julia BESPYATYKH, PhD, Researcher

Maria KORNIENKO, PhD, Researcher

Maya MALAKHOVA, PhD, Researcher

Ivan BODOEV, Junior Researcher

Roman GORODNICHEV, Junior Researcher

Dmitry BESPIATYKH, Lab Assistant

Nikita KUPTSOV, Lab Assistant

 

Students

Ekaterina Shepeleva, MIPT

Konstantin Phyhtin, D.Mendeleev UCTR

Dmitry Danilov, MSMU

Scientific Interests and Research Areas

Scientific Interests and Research Areas

Lab of Molecular Genetics of Microorganisms was established in 2004 by the former head of Lab Prof. Elena N. Ilina. Our team is mainly focused on studying the molecular peculiarities of drug resistance formation in microorganisms and ways to overcome resistance. In addition, we are solving local problems related to molecular typing of microbial populations and the development of new ways of bacterial species identification. The main research areas include:

  • Mycobacterium tuberculosis: Study of mechanisms of drug resistance and pathogenicity factors mycobacteria strains, which are endemic to Russia, using genomic, transcriptomic and proteomic methods. Description of population structure of the pathogen.
  • Study of the interaction of virulent bacteriophages with ESKAPE pathogens (bacterial pathogens belonging to the species Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) in order to update the principles of  phage therapy.
  • Neisseria gonorrhoeae: Decoding of new molecular mechanisms of gonococcus resistance to various antibiotics (penicillin, ceftriaxone and spectinomycin) used in the treatment of gonorrhea.
  • Escherichia coli: Study of formation of mutants resistant to quinolones or aminocoumarin in strains with defective proteins, responsible for the DNA strands transport, the SOS-response system and the 3R system (RecA, LexA repressor, and DNA-helicase II).
  • Adherent-invasive E. сoli (AIEC): Study of the microorganism as a possible causative agent for Crohn's disease. Study of biological pathways of the effect of AIEC virulence factors on human intestinal cells.

Research Projects

Research Projects

  • RSF grant “Genomic G-quadruplexes of Mycobacterium tuberculosis as potential targets for new anti-tuberculosis drugs” (2019-2021)
  • FMBA of Russia “Development of a personalized approach to the therapy of infectious processes using virulent bacteriophages” (2019-2021)
  • RFBR grant “Role of the repeating element IS6110 in the micro- and macroevolution of Mycobacterium tuberculosis phylogenetic lineage 2” (2018–2019)
  • RFBR grant “Proteogenomic Characteristic of Mycobacterium tuberculosis Beijing B0/W148 cluster” (2018–2019)
  • RSF grant “System study of Mycobacterium tuberculosis Beijing clonal groups endemic in Russia” (2017-2019)
  • RSF grant “The search for new activators of the destruction of biofilms based on proteomic analysis of catheter-related biofilm formed under conditions in vivo and in vitro” (2015–2017)
  • RFBR grant “Deciphering the molecular mechanisms of manifestation of pathogenicity of coagulase negative staphylococci” (2015–2017)
  • RSF grant “Characteristic of proteins expressed by tuberculosis Beijing B0 cells under the in vitro and in vivo conditions” (2014–2016)
  • Grant of the Ministry of Education and Science of the Russian Federation “Development and production of prototype test system for the detection of drug-resistant tuberculosis in view of features of genomic organization strains endemic to Russia” (2012–2013)
  • NPO "Microgen" "Molecular genetic study of the vaccine strain Mycobacterium bovis BCG”
  • Research & Development Contract No BDALIPCM 270505 “Development and commercial introduction of novel approaches for the characterization of different diseases as well as identification of clinically relevant microorganisms” (2010–2012)

PhD Theses

PhD Theses

2016: Maria A. Kornienko PhD in Genetics, PhD thesis “Biochemical and genetic features of realization of the pathogenicity of hospital strains of Staphylococcus epidermidis and Staphylococcus haemolyticus

2016: Julia A. Bespyatykh PhD in Biochemistry, PhD thesis “Genomic and proteomic characterization of strains of Mycobacterium tuberculosis Beijing B0/W148 cluster”

2014: Egor A. Shitikov PhD in Biochemistry, PhD thesis “Genomic variability of pathogens of drug-resistant tuberculosis, common in the Russian Federation”

2011: Tatiana A. Savinova PhD in Microbiology and Molecular Biology, PhD thesis “Genetic diversity and the molecular basis of resistance of Streptococcus pneumoniae to beta-lactam antibiotics”

2010: Daria E. Mudrak PhD in Microbiology and Molecular Biology, PhD thesis “Molecular genetic features of resistance to beta-lactam antibiotics of Gram-negative microorganisms, causative agents of nosocomial infections”

2009: Elena N. Ilina DSc in Biochemistry, Doctoral thesis “Establishment of integrated genome-proteomic systems for typing and study of pathogens of bacterial and viral nature”

2008: Maxim V. Afanasiev PhD in Biochemistry, PhD thesis “Molecular typing of clinical isolates of Mycobacterium tuberculosis

2006: Vladimir A. Vereschagin PhD in Biochemistry and Molecular Biology, PhD thesis “Molecular typing of clinical isolates of Neisseria gonorrhoeae

Scientific Collaboration

Scientific Collaboration

Our Lab has joint research projects with the following organizations:

  • University of Ostrava, Ostrava, Czech Republic
  • Research Center Borstel, Borstel, Germany
  • Research Centre of Biotechnology RAS, Moscow
  • Winogradsky Institute of Microbiology, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences, Moscow
  • Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow
  • Central Research Institute of Tuberculosis, Moscow
  • Gamaleya Federal Research Centre of Epidemiology and Microbiology, Moscow
  • Research Center for Obstetrics, Gynecology and Perinatology, Russian Ministry of Healthcare, Moscow
  • Pasteur Research Institute of Epidemiology and Microbiology, Petersburg
  • Petersburg Research Institute for Phthisiopulmonology, St. Petersburg
  • Research Institute of Antimicrobial Chemotherapy, Smolensk
  • Novosibirsk TB Research Institute, Novosibirsk
  • Ural Research Institute for Phthisiopulmonology, Yekaterinbur
  • Institute of Molecular Genetics Russian Academy of Sciences, Moscow

 

Publications

Publications

  1. Simple assay to detect Central Asia Outbreak clade of Mycobacterium tuberculosis Beijing genotype. Shitikov E., Vyazovaya A., Malakhova M., Guliaev A., Bespyatykh J., Proshina E., Pasechnik O., Mokrousov I. J. Clin. Microbiol. JCM.00215-19 doi:10.1128/JCM.00215-19
    (https://jcm.asm.org/content/57/7/e00215-19)
  2. The role of IS6110 in micro- and macroevolution of Mycobacterium tuberculosis lineage 2. Egor Shitikov, Andrei Guliaev, Julia Bespyatykh, Maja Malakhova, Sergey Kolchenko, Georgy Smirnov, Mathias Merker, Stefan Niemann, Igor Mokrousov, Elena Ilina, Vadim Govorun. Molecular Phylogenetics and Evolution. July 2019. DOI: 10.1016/j.ympev.2019.106559
    (https://www.sciencedirect.com/science/article/pii/S1055790319300806?via%3Dihub)
  3. Proteogenomic analysis of Mycobacterium tuberculosis Beijing B0/W148 cluster strains. Julia Bespyatykh; Alexander Smolyakov; Andrei Guliaev; Egor Shitikov; Georgij Arapidi; Ivan Butenko; Marine Dogonadze; Olga Manicheva; Elena Ilina; Victor Zgoda; Vadim Govorun. Journal of Proteomics, 2018 Jul 13. pii: S1874-3919(18)30274-4. doi: 10.1016/j.jprot.2018.07.002.
    (https://www.sciencedirect.com/science/article/pii/S1874391918302744?via%3Dihub)
  4. Bespyatykh J.A., Manicheva O.A., Smolyakov A.V., Dogonadze M.Z., Zhuravlev V.Yu., Shitikov E.A., Ilina E.N. The Influence of Cultivation Conditions on the Proteomic Profile of Mycobacterium tuberculosis H37Rv // Biomedical Chemistry, 2018, Vol. 12, No. 1, pp. 32–38. ISSN 1990-7508. DOI: 10.18097/PBMC2.
  5. Shitikov E, Kolchenko S, Mokrousov I, Bespyatykh J, Ischenko D, Ilina E, Govorun V. Evolutionary pathway analysis and unified classification of East Asian lineage of Mycobacterium tuberculosis. // Scientific Reports. – 2017. – V. 7. – P. 10.1038/s41598-017-10018-5. doi:10.1038/s41598-017-10018-5.
  6. Mokrousov I, Shitikov E, Skiba Y, Kolchenko S, Chernyaeva E, Vyazovaya A. Emerging peak on the phylogeographic landscape of Mycobacterium tuberculosis in West Asia: Definitely smoke, likely fire. Mol Phylogenet Evol. 2017 Nov;116:202-212. IF4.419. doi: 10.1016/j.ympev.2017.09.002.
  7. Terekhov SS, Smirnov IV, Stepanova AV, Bobik TV, Mokrushina YA, Ponomarenko NA, Belogurov AA Jr, Rubtsova MP, Kartseva OV, Gomzikova MO, Moskovtsev AA, Bukatin AS, Dubina MV, Kostryukova ES, Babenko VV, Vakhitova MT, Manolov AI, Malakhova MV, Kornienko MA, Tyakht AV, Vanyushkina AA, Ilina EN, Masson P, Gabibov AG, Altman S. Microfluidic droplet platform for ultrahigh-throughput single-cell screening of biodiversity. Proc Natl Acad Sci U S A. – 2017 – V.114(10) – p.2550-2555. doi: 10.1073/pnas.1621226114.
  8. Glushchenko OE, Samoilov AE, Olekhnovich EI, Kovarsky BA, Tyakht AV, Pavlenko AV, Babenko VV, Larin AK, Kostryukova ES, Malakhova MV, Ilina EN, Abdulkhakov RA, Safina DI, Grigoryeva TV, Abdulkhakov SR, Govorun VM. Data on gut metagenomes of the patients with Helicobacter pylori infection before and after the antibiotic therapy. Data Brief. 2017 Jan 17;11:68-71. doi: 10.1016/j.dib.2017.01.007.
  9. Bespyatykh JA, Shitikov EA, Ilina EN. Proteomics for the Investigation of Mycobacteria. Acta Naturae. 2017 Jan-Mar;9(1):15-25.
  10. Terekhov SS, Smirnov IV, Stepanova AV, Bobik TV, Mokrushina YA, Ponomarenko NA, Belogurov AA Jr, Rubtsova MP, Kartseva OV, Gomzikova MO, Moskovtsev AA, Bukatin AS, Dubina MV, Kostryukova ES, Babenko VV, Vakhitova MT, Manolov AI, Malakhova MV, Kornienko MA, Tyakht AV, Vanyushkina AA, Ilina EN, Masson P, Gabibov AG, Altman S. Microfluidic droplet platform for ultrahigh-throughput single-cell screening of biodiversity. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2550-2555.
  11. Glushchenko OE, Samoilov AE, Olekhnovich EI, Kovarsky BA, Tyakht AV, Pavlenko AV, Babenko VV, Larin AK, Kostryukova ES, Malakhova MV, Ilina EN, Abdulkhakov RA, Safina DI, Grigoryeva TV, Abdulkhakov SR, Govorun VM. Data on gut metagenomes of the patients with Helicobacter pylori infection before and after the antibiotic therapy. Data Brief. 2017 Jan 17;11:68-71. doi: 10.1016/j.dib.2017.01.007.
  12. Bespyatykh J., Shitikov E., Butenko I., Altukhov I., Alexeev D., Mokrousov I., Dogonadze M., Zhuravlev V., Yablonsky P., Ilina E., Govorun V. Proteome analysis of the Mycobacterium tuberculosis Beijing B0/W148 cluster. Scientific Reports. 2016. 6, 28985; doi: 10.1038/srep28985. (http://www.nature.com/articles/srep28985)
  13. Kornienko М., Ilina E., Lubasovskaya L., Priputnevich T., Falova O., Sukchikch G., Govorun V. Analysis of nosocomial Staphylococcus haemolyticus by MLST and MALDI-TOF Mass Spectrometry. Infection, Genetics and Evolution, (2016), pp. 99-105.
  14. Kornienko MA, Kopyltsov VN, Shevlyagina NV, Didenko LV, Lyubasovskaya LA, Priputnevich TV,Ilina EN. [Ability of Staphylococcus of various strains to create biofilms and their effect on human body cells].Mol Gen Mikrobiol Virusol. 2016;34(1):18-25. In Russian. (https://link.springer.com/article/10.3103/S0891416816010055)
  15. Sotnikova EA, Shitikov EA, Malakhova MV, Kostryukova ES, Ilina EN, Atrasheuskaya AV, Ignatyev GM, Vinokurova NV, Gorbachyov VY. Complete Genome Sequence of Mycobacterium bovis Strain BCG-1 (Russia) Genome Announc. 2016 Mar 31;4(2). pii: e00182-16. doi: 10.1128/genomeA.00182-16 (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816620/)
  16. Bodoev IN, Il'ina EN. [Molecular mechanisms of drug resistance Neisseria gonorrhoeae history and prospects]. Mol Gen Mikrobiol Virusol. 2015;30(3):132-140. Review. In Russian.
  17. Chaplin AV, Brzhozovskii AG, Parfenova TV, Kafarskaia LI, Volodin NN, Shkoporov AN, Ilina EN, Efimov BA. [Species Diversity of Bifidobacteria in the Intestinal Microbiota Studied Using MALDI-TOF Mass-Spectrometry]. Vestn Ross Akad Med Nauk. 2015;(4):435-40. In
  18. Ikryannikova L.N., Ischenko D.S., Kanygina A.V., Karpova I.Y., Kostryukova E.S., Ilina E.N., Govorun V.M., Lominadze G.G., Mayansky N.A., Skvortsov V.S. The mystery of the fourth clone: comparative genomic analysis of four non-typeable Streptococcus pneumoniae strains with different susceptibilities to optochin European Journal of Clinical Microbiology & Infectious Diseases. 2015.
  19. Chernyaeva E.N., Rotkevich M.S., Dobrynin P.V., Simonov S.A., Lapidus A.L., O’Brien S.J., Shulgina M.V., Zhuravlev V.Y., Manicheva O.A., Yablonsky P.K., Shitikov E.A., Ischenko D.S., Karpova I.Y., Kostryukova E.S., Ilina E.N., Govorun V.M., Isaeva Y.D., Nosova E.Y., Mokrousov I.V., Vyazovaya A.A. et al. Genome-wide Mycobacterium tuberculosis variation (GMTV) database: a new tool for integrating sequence variations and epidemiology. BMC Genomics. Т. 15. № 1. С. 308
  20. Bespyatykh J. A., Shitikov E. A., Ilina E. N., Govorun V. M., Zimenkov D. V., Kulagina E. V., Lapa S. A., Gryadunov D. A. Spoligotyping of Mycobacterium tuberculosis complex isolates using hydrogel oligonucleotide microarrays. Infection, Genetics and Evolution. 2014. Т. 26. С. 41-46
  21. Shitikov E.A., Bespyatykh J.A., Ischenko D.S., Alexeev D.G., Karpova I.Y., Kostryukova E.S., Isaeva Y.D., Nosova E.Y., Mokrousov I.V., Vyazovaya A.A., Narvskaya O.V., Vishnevsky B.I., Otten T.F., Zhuravlev V.Y.,Yablonsky P.K., Govorun V.M Unusual Large-Scale Chromosomal Rearrangements in Mycobacterium tuberculosis Beijing B0/W148 Cluster Isolates. PLOS ONE, 2014, 9 (1), e84971
  22. Zimenkov DV, Kulagina EV, Antonova OV, Surzhikov SA, Bespiatykh IuA, Shitikov EA, Il'ina EN, Mikhaĭlovich VM, Zasedatelev AS, Griadunov DA. [Analysis of genetic determinants of multidrug and extensively drug-resistant Mycobacterium tuberculosis using oligonucleotide microchip]. Mol Biol (Mosk). 2014 Mar-Apr;48(2):251-64. In Russian
  23. Bespyatykh Y.A., Shitikov E.A., Zimenkov D.V., Kulagina E.V., Gryadunov D.A., Nosova E.Y., Bukatina А.А., Shulgina M.V., Zhuravlev V.Y., Ilyina E.N. Identification of drug resistance and genotyping of clinical isolates of Mycobacterium tuberculosis using the TB-TEST.Russian Pulmonology. 2013;(4):77-81. In Russian
  24. Агеевец В.А., Партина И.В., Лисицына Е.С., Батыршин И.М., Попенко Л.Н., Шляпников С.А., Ильина Е.Н., Сидоренко С.В. Чувствительность грамотрицательных бактерий, продуцентов карбапенемаз, к антибиотикам различных групп. Антибиотики и химиотерапия, 2013.-N 3.-С.10-13.
  25. Ilina EN, Malakhova MV, Bodoev IN, Oparina NY, Filimonova AV, Govorun VM. Mutation in ribosomal protein S5 leads to spectinomycin resistance inNeisseria gonorrhoeae. Frontiers in M 01/2013; 4:186. doi: 10.3389/fmicb.2013.00186.
  26. Любасовская Л.А., Корниенко М.А., Припутневич Т.В., Ильина Е.Н., Щеголев А.И. Микробиологическая и молекулярно-генетическая характеристика коагулазонегативных стафилококков, выделенных у новорожденных отделения реанимации и интенсивной терапии.«Антибиотики и химиотерапия», 2013, 58; 3-4, 26 – 33
  27. Ilina EN, Shitikov EA, Ikryannikova LN, Alekseev DG, Kamashev DE, Malakhova MV, Parfenova TV, Afanas’ev MV, Ischenko DS, Bazaleev NA, Smirnova TG, Larionova EE, Chernousova LN, Beletsky AV, Mardanov AV, Ravin NV, Skryabin KG, Govorun VM. Comparative Genomic Analysis of Mycobacterium tuberculosis Drug Resistant Strains from Russia. PLoS ONE, 2013, 8(2): e56577. doi:10.1371/journal.pone.0056577
  28. Ikryannikova LN, Filimonova AV, Malakhova MV, Savinova T, Filimonova O, Ilina EN, Dubovickaya VA, Sidorenko SV, Govorun VM. Discrimination between pneumoniae and S. mitis based on sorting of their MALDI mass spectra. Clin Microbiol Infect. 2013 Nov; 19(11):1066-71. doi: 10.1111/1469-0691
  29. Kushnir AV, Ilina EN, Malakhova MV, Priputnevich TV, Filipenko ML. Multiple-locus variable number tandem repeat analysis of Neisseria gonorrhoeaeisolates in Russia. Infect Genet Evol. 2012 Dec 19; 14C:8. doi: Infect Genet Evol. 2013 Mar; 14:8-14. doi: 10.1016/j.meegid.2012.11.020
  30. Корниенко М.А., Ильина Е.Н., Боровская А.Д., Эдельштейн M.В., Сухорукова M.В., Кострцева М., Говорун В.М. Прямое бактериальное профилирование посредством MALDI масс-спектрометрии как метод быстрой классификации штаммов Staphylococcus aureus. Биомедицинская химия, 2012. Т. 58 N 5.-С.501-513.
  31. Shitikov E1, Ilina E, Chernousova L, Borovskaya A, Rukin I, Afanas’ev M, Smirnova T, Vorobyeva A, Larionova E, Andreevskaya S, Kostrzewa M, Govorun V. Mass spectrometry based methods for the discrimination and typing of mycobacteria. Infect Genet Evol. 2012 Jun; 12(4):838-45. doi: 10.1016/j.meegid.2011.12.013.
  32. Shevchenko OV, Mudrak DY, Skleenova EY, Kozyreva VK, Ilina EN, Ikryannikova LN, Alexandrova IA, Sidorenko SV, Edelstein MV. First detection of VIM-4 metallo-β-lactamase-producing Escherichia coli in Russia. Clin Microbiol Infect. 2012 Jul; 18(7):E214-7. doi: 10.1111/j.1469-0691.2012.03827.x. Epub 2012 Apr 4.
  33. Zubritskiĭ AV, Il’ina EN, Strel’chenko SA, Malakhova MV, Lenev SV, Skliarov OD, Panin AN, Govorun VM . Investigation of molecular mechanisms of aminoglycoside resistance in Salmonella. Antibiot Khimioter. 2011; 56(9-10):7-12. (In Russian).
  34. Ikryannikova LN, Lapin KN, Malakhova MV, Filimonova AV, Ilina EN, Dubovickaya VA, Sidorenko SV, Govorun VM. Misidentification of alpha-hemolytic streptococci by routine tests in clinical practice. Infect Genet Evol. 2011 Oct; 11(7):1709-15.
  35. Afanas’ev MV., Ikryannikova LN., Il’ina EN., Kuz’min AV., Larionova EE., Smirnova TG., Chernousova LN. and Govorun VM. Molecular typing of Mycobacterium tuberculosis circulated in Moscow, Russian Federation. Eur J Clin Microbiol Infect Dis. 2011 Feb; 30(2):181-91. doi: 10.1007/s10096-010-1067-z.
  36. Боровская А. Д., Ильина Е. Н., Савинова Т. А., Сидоренко С. В., Грудинина С. А., Говорун В. М. Дифференцировка α-гемолитических стрептококков прямым масс-спектрометрическим профилированием. Биоорганическая химия, 2011, том 37, № 1, с. 61–69
  37. Ilina EN1, Borovskaya AD, Serebryakova MV, Chelysheva VV, Momynaliev KT, Maier T, Kostrzewa M, Govorun VM. Application of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for the study of Helicobacter pylori. Rapid Commun Mass Spectrom. 2010 Feb; 24(3):328-34. doi: 10.1002/rcm.4394.
  38. Афанасьев М.В., Каракашев С.В., Ильина Е.Н., Салем А.-С.-А.-М. , Сидоренко С.В. и Говорун В.М. Молекулярно-генетическая характеристика метициллин-устойчивых штаммов Staphylococcusaureus, выделенных в стационарах г. Москвы. Журнал «Молекулярная генетика, микробиология и вирусология» 2010, № 2, стр.20-24
  39. Ikryannikova LN., Shkarupeta MM., Shitikov EA., Il’ina EN., Govorun VM. Comparative evaluation of new typing schemes for urogenital Chlamydia trachomatis isolates. FEMS Immunol Med Microbiol. 2010, Jul 1; 59(2):188-96. doi: 10.1111/j.1574-695X.2010.00678.x
  40. Савинова Т.А., Ильина Е.Н., Сидоренко С.В. Масс-спектрометрический анализ генетических маркеров резистентности pneumoniae к бета-лактамным антибиотикам. Журнал «Молекулярная генетика, микробиология и вирусология» 2010, № 3
  41. Ilina EN, Oparina NY, Shitikov EA, Borovskaya AD, Govorun VM. Molecular surveillance of clinical Neisseria gonorrhoeae isolates in Russia. J of Clinical Microbiology, 2010 Oct; 48(10):3681-9
  42. Афанасьев М.В., Боровская А.Д., Ильина Е.Н., Смирнова Т.Г., Ларионова Е.Е., Кузьмин А.В., Андреевская С.Н., Черноусова Л.Н., Говорун В.М. Выявление мутаций в 306 кодоне embB гена для молекулярно-генетической характеристики клинических штаммов Mycobacterium tuberculosis. Пробл. тубер. болезн. легких. — 2009. — № 5. — C. 48 — 53.
  43. Малахова М.В., Ильина Е.Н., Говорун В.М., Шутько С.А., Дудина К.Р., Знойко О.О., Климова Е.А., Ющук Н.Д. Масс-спектрометрическое генотипирование вируса гепатита В. Бюлл. экспер. биол. мед. – 2009. – Т. 147. – № 2. – С. 181 — 187.
  44. Ильина Е.Н., Говорун В.М. Масс-спектрометрия нуклеиновых кислот в молекулярной медицине. Биоорганическая химия. – 2009. – Т. 35. – №. 2. – C. 149 — 164.
  45. Владимиров Г.Н., Кононихин А.С., Ильина Е.Н., Говорун В.М., Николаев Е.Н. Точное измерение масс продуктов полимеразно-цепной реакции как метод генотипирования. Труды МФТИ. – 2009. – Т. 1. — № 1. – C. 36 – 40.
  46. Ilina EN, Borovskaya AD, Malakhova MM, Vereshchagin VA, Kubanova AA, Kruglov AN, Svistunova TS, Gazarian AO, Maier T, Kostrzewa M, Govorun VM. Direct bacterial profiling by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry for identification of pathogenicNeisseria. J Mol Diagn. 2009 11(1):75-86. doi: 10.2353/jmoldx.
  47. Атрошкина М.Е., Ильина Е.Н., Плахова К.И., Гомберг М.А., Кубанова А.А., Говорун В.М. Разработка ДНК- биочипа для исследования микробных сообществ. Молекулярная медицина. — 2009.- 3. — С.23 -31.
  48. Mellmann A, Bimet F, Bizet C, Borovskaya AD, Drake RR, Eigner U, Fahr AM, He Y, Ilina EN, Kostrzewa M, Maier T, Mancinelli L, Moussaoui W, Prévost G, Putignani L, Seachord CL, Tang YW, Harmsen D. High interlaboratory reproducibility of matrix-assisted laser desorption ionization-time of flight mass spectrometry-based species identification of nonfermenting bacteria. J Clin Microbiol. 2009 Nov; V. 47, N. 11, P. 3732-3734. doi: 10.1128/JCM.00921-09
  49. Ilina EN1, Vereshchagin VA, Borovskaya AD, Malakhova MV, Sidorenko SV, Al-Khafaji NC, Kubanova AA, Govorun VM. Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. Antimicrobial Agents And Chemotherapy, 2008 Jun; 52(6):2175-82. doi: 10.1128/AAC.01420-07
  50. Ikryannikova LN, Shitikov EA, Zhivankova DG, Il’ina EN, Edelstein MV, Govorun VM. A MALDI TOF MS-based minisequencing method for rapid detection of TEM-type extended-spectrum beta-lactamases in clinical strains of Enterobacteriaceae. J Microbiol Methods. 2008 Dec; 75(3):385-91. doi: 10.1016/j.mimet.2008.07.005.
  51. Reinert RR, Filimonova OY, Al-Lahham A, Grudinina SA, Ilina EN, Weigel LM, Sidorenko SV. Mechanisms of macrolide resistance among Streptococcus pneumoniae isolates from Russia. Antimicrob Agents Chemother. 2008 Jun; 52(6):2260-2. doi: 10.1128/AAC.01270-07.
  52. Ющук Н.Д., Знойко О.О., Климова Е.А., Дудина К.Р., Кареткина Г.Н., Ильина Е.Н., Максимова С.Л. Генетическая изменчивость вирусов гепатита человека и ее клиническое значение. Москва, 2007 год.
  53. Боровская А.Д., Малахова М.В., Верещагин В.А., Ильина Е.Н., Говорун В.М., Припутневич Т.В., Аль-Хафаджи Н., Кубанова А.А. Анализ вклада молекулярных механизмов в формирование устойчивости гонококка к тетрациклину. Журнал «Бюллетень экспериментальной биологии и медицины», 2007, приложение 2, стр. 61 — 66.
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