Lab of Molecular Genetics of Microorganisms

Meet our team

Meet our team

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Acting Head of the Lab
Egor Shitikov, PhD
 
George B. Smirnov, DSc., Professor, Chief Scientific Officer

Larisa N. Ikryannikova, PhD, Senior Researcher

Maya V. Malakhova, PhD, Researcher

Julia A. Bespyatykh, PhD, Junior Researcher

Maria A. Kornienko, PhD, Junior Researcher

Ivan N. Bodoev, Junior Researcher

Roman B. Gorodnichev, Junior Researcher

Nikita S. Kuptsov, Lab Assistant

Sergey A. Kolchenko, Student

Alina V. Polonskaya, Student

Alexander V. Smolyakov, Student

About our work

Scientific Interests and Research Areas

Lab of Molecular Genetics of Microorganisms was established in 2004 by the former head of Lab Prof. Elena N. Ilina. Our team is mainly focused on molecular patterns of drug resistance formation in microorganisms. In addition, we are solving local problems related to molecular typing of microbial populations and creation of new ways of bacteria species identification. The main research areas include:

  • Neisseria gonorrhoeae: Decoding of new molecular mechanisms of gonococcus resistance to various antibiotics (penicillin, ceftriaxone and spectinomycin) used in treatment of gonorrhea.
  • Mycobacterium tuberculosis: Study of mechanisms of drug resistance and pathogenicity factors of Beijing B0/W148 strains, which are endemic to Russia, using genomic and proteomic methods. Description of population structure of the pathogen.
  • Escherichia coli: Study of formation of mutants resistant to quinolones or aminocoumarin in strains with defective proteins, responsible for the DNA strands transport, the SOS-response system and the 3R system (RecA, LexA repressor, and DNA-helicase II).
  • Adherent-invasive сoli (AIEC): Study of the microorganism as a possible causative agent for Crohn's disease. Study of biological pathways of the effect of AIEC virulence factors on human intestinal cells.
  • Coagulase-Negative Staphylococci: Study of manifestation of pathogenic properties of nosocomial strains, study of processes in the formation of biofilms.
  • Streptococcus pneumoniae: Study of intra- and interspecific relationship.

 

Research Grants

  • RSF grant “System study of Mycobacterium tuberculosis Beijing clonal groups endemic in Russia” (2017-2019)
  • RSF grant “The search for new activators of the destruction of biofilms based on proteomic analysis of catheter-related biofilm formed under conditions in vivo and in vitro” (2015–2017)
  • RFBR grant “Deciphering the molecular mechanisms of manifestation of pathogenicity of coagulase negative staphylococci” (2015–2017)
  • RSF grant “Characteristic of proteins expressed by tuberculosis Beijing B0 cells under the in vitro and in vivo conditions” (2014–2016)
  • Grant of the Ministry of Education and Science of the Russian Federation “Development and production of prototype test system for the detection of drug-resistant tuberculosis in view of features of genomic organization strains endemic to Russia” (2012–2013)
  • Research & Development Contract No BDALIPCM 270505 “Development and commercial introduction of novel approaches for the characterization of different diseases as well as identification of clinically relevant microorganisms” (2010–2012)

 

PhD Theses

2016: Maria A. Kornienko PhD in Genetics, PhD thesis “Biochemical and genetic features of realization of the pathogenicity of hospital strains of Staphylococcus epidermidis and Staphylococcus haemolyticus

2016: Julia A. Bespyatykh PhD in Biochemistry, PhD thesis “Genomic and proteomic characterization of strains of Mycobacterium tuberculosis Beijing B0/W148 cluster”

2014: Egor A. Shitikov PhD in Biochemistry, PhD thesis “Genomic variability of pathogens of drug-resistant tuberculosis, common in the Russian Federation”

2011: Tatiana A. Savinova PhD in Microbiology and Molecular Biology, PhD thesis “Genetic diversity and the molecular basis of resistance of Streptococcus pneumoniae to beta-lactam antibiotics”

2010: Daria E. Mudrak PhD in Microbiology and Molecular Biology, PhD thesis “Molecular genetic features of resistance to beta-lactam antibiotics of Gram-negative microorganisms, causative agents of nosocomial infections”

2009: Elena N. Ilina DSc in Biochemistry, Doctoral thesis “Establishment of integrated genome-proteomic systems for typing and study of pathogens of bacterial and viral nature”

2008: Maxim V. Afanasiev PhD in Biochemistry, PhD thesis “Molecular typing of clinical isolates of Mycobacterium tuberculosis

2006: Vladimir A. Vereschagin PhD in Biochemistry and Molecular Biology, PhD thesis “Molecular typing of clinical isolates of Neisseria gonorrhoeae

 

Scientific Collaboration

Our Lab has joint research projects with the following organizations:

  • N. Winogradsky Institute of Microbiology, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences, Moscow
  • A. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow
  • Center of Bioengineering, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences, Moscow
  • Central Research Institute of Tuberculosis, Moscow
  • F. Gamaleya Federal Research Centre of Epidemiology and Microbiology, Moscow
  • V. Sklifosovsky Research Institute of Emergency Medicine, Moscow
  • I. Research Center for Obstetrics, Gynecology and Perinatology, Russian Ministry of Healthcare, Moscow
  • Pasteur Research Institute of Epidemiology and Microbiology, Petersburg
  • Petersburg Research Institute for Phthisiopulmonology, St. Petersburg
  • Research Institute of Antimicrobial Chemotherapy, Smolensk
  • Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk
  • Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk
  • Novosibirsk TB Research Institute, Novosibirsk
  • Ural Research Institute for Phthisiopulmonology, Yekaterinburg

 

Publications

Publications

  1. Bespyatykh JA, Shitikov EA, Ilina EN. Proteomics for the Investigation of Mycobacteria. Acta Naturae. 2017 Jan-Mar;9(1):15-25.
  2. Terekhov SS, Smirnov IV, Stepanova AV, Bobik TV, Mokrushina YA, Ponomarenko NA, Belogurov AA Jr, Rubtsova MP, Kartseva OV, Gomzikova MO, Moskovtsev AA, Bukatin AS, Dubina MV, Kostryukova ES, Babenko VV, Vakhitova MT, Manolov AI, Malakhova MV, Kornienko MA, Tyakht AV, Vanyushkina AA, Ilina EN, Masson P, Gabibov AG, Altman S. Microfluidic droplet platform for ultrahigh-throughput single-cell screening of biodiversity. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2550-2555.
  3. Glushchenko OE, Samoilov AE, Olekhnovich EI, Kovarsky BA, Tyakht AV, Pavlenko AV, Babenko VV, Larin AK, Kostryukova ES, Malakhova MV, Ilina EN, Abdulkhakov RA, Safina DI, Grigoryeva TV, Abdulkhakov SR, Govorun VM. Data on gut metagenomes of the patients with Helicobacter pylori infection before and after the antibiotic therapy. Data Brief. 2017 Jan 17;11:68-71. doi: 10.1016/j.dib.2017.01.007.
  4. Bespyatykh J., Shitikov E., Butenko I., Altukhov I., Alexeev D., Mokrousov I., Dogonadze M., Zhuravlev V., Yablonsky P., Ilina E., Govorun V. Proteome analysis of the Mycobacterium tuberculosis Beijing B0/W148 cluster. Scientific Reports. 2016. 6, 28985; doi: 10.1038/srep28985. (http://www.nature.com/articles/srep28985)
  5. Kornienko М., Ilina E., Lubasovskaya L., Priputnevich T., Falova O., Sukchikch G., Govorun V. Analysis of nosocomial Staphylococcus haemolyticus by MLST and MALDI-TOF Mass Spectrometry. Infection, Genetics and Evolution, (2016), pp. 99-105.
  6. Kornienko MA, Kopyltsov VN, Shevlyagina NV, Didenko LV, Lyubasovskaya LA, Priputnevich TV,Ilina EN. [Ability of Staphylococcus of various strains to create biofilms and their effect on human body cells].Mol Gen Mikrobiol Virusol. 2016;34(1):18-25. In Russian. (https://link.springer.com/article/10.3103/S0891416816010055)
  7. Sotnikova EA, Shitikov EA, Malakhova MV, Kostryukova ES, Ilina EN, Atrasheuskaya AV, Ignatyev GM, Vinokurova NV, Gorbachyov VY. Complete Genome Sequence of Mycobacterium bovis Strain BCG-1 (Russia) Genome Announc. 2016 Mar 31;4(2). pii: e00182-16. doi: 10.1128/genomeA.00182-16 (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816620/)
  8. Bodoev IN, Il'ina EN. [Molecular mechanisms of drug resistance Neisseria gonorrhoeae history and prospects]. Mol Gen Mikrobiol Virusol. 2015;30(3):132-140. Review. In Russian.
  9. Chaplin AV, Brzhozovskii AG, Parfenova TV, Kafarskaia LI, Volodin NN, Shkoporov AN, Ilina EN, Efimov BA. [Species Diversity of Bifidobacteria in the Intestinal Microbiota Studied Using MALDI-TOF Mass-Spectrometry]. Vestn Ross Akad Med Nauk. 2015;(4):435-40. In
  10. Ikryannikova L.N., Ischenko D.S., Kanygina A.V., Karpova I.Y., Kostryukova E.S., Ilina E.N., Govorun V.M., Lominadze G.G., Mayansky N.A., Skvortsov V.S. The mystery of the fourth clone: comparative genomic analysis of four non-typeable Streptococcus pneumoniae strains with different susceptibilities to optochin European Journal of Clinical Microbiology & Infectious Diseases. 2015.
  11. Chernyaeva E.N., Rotkevich M.S., Dobrynin P.V., Simonov S.A., Lapidus A.L., O’Brien S.J., Shulgina M.V., Zhuravlev V.Y., Manicheva O.A., Yablonsky P.K., Shitikov E.A., Ischenko D.S., Karpova I.Y., Kostryukova E.S., Ilina E.N., Govorun V.M., Isaeva Y.D., Nosova E.Y., Mokrousov I.V., Vyazovaya A.A. et al. Genome-wide Mycobacterium tuberculosis variation (GMTV) database: a new tool for integrating sequence variations and epidemiology. BMC Genomics. Т. 15. № 1. С. 308
  12. Bespyatykh J. A., Shitikov E. A., Ilina E. N., Govorun V. M., Zimenkov D. V., Kulagina E. V., Lapa S. A., Gryadunov D. A. Spoligotyping of Mycobacterium tuberculosis complex isolates using hydrogel oligonucleotide microarrays. Infection, Genetics and Evolution. 2014. Т. 26. С. 41-46
  13. Shitikov E.A., Bespyatykh J.A., Ischenko D.S., Alexeev D.G., Karpova I.Y., Kostryukova E.S., Isaeva Y.D., Nosova E.Y., Mokrousov I.V., Vyazovaya A.A., Narvskaya O.V., Vishnevsky B.I., Otten T.F., Zhuravlev V.Y.,Yablonsky P.K., Govorun V.M Unusual Large-Scale Chromosomal Rearrangements in Mycobacterium tuberculosis Beijing B0/W148 Cluster Isolates. PLOS ONE, 2014, 9 (1), e84971
  14. Zimenkov DV, Kulagina EV, Antonova OV, Surzhikov SA, Bespiatykh IuA, Shitikov EA, Il'ina EN, Mikhaĭlovich VM, Zasedatelev AS, Griadunov DA. [Analysis of genetic determinants of multidrug and extensively drug-resistant Mycobacterium tuberculosis using oligonucleotide microchip]. Mol Biol (Mosk). 2014 Mar-Apr;48(2):251-64. In Russian
  15. Bespyatykh Y.A., Shitikov E.A., Zimenkov D.V., Kulagina E.V., Gryadunov D.A., Nosova E.Y., Bukatina А.А., Shulgina M.V., Zhuravlev V.Y., Ilyina E.N. Identification of drug resistance and genotyping of clinical isolates of Mycobacterium tuberculosis using the TB-TEST.Russian Pulmonology. 2013;(4):77-81. In Russian
  16. Агеевец В.А., Партина И.В., Лисицына Е.С., Батыршин И.М., Попенко Л.Н., Шляпников С.А., Ильина Е.Н., Сидоренко С.В. Чувствительность грамотрицательных бактерий, продуцентов карбапенемаз, к антибиотикам различных групп. Антибиотики и химиотерапия, 2013.-N 3.-С.10-13.
  17. Ilina EN, Malakhova MV, Bodoev IN, Oparina NY, Filimonova AV, Govorun VM. Mutation in ribosomal protein S5 leads to spectinomycin resistance inNeisseria gonorrhoeae. Frontiers in M 01/2013; 4:186. doi: 10.3389/fmicb.2013.00186.
  18. Любасовская Л.А., Корниенко М.А., Припутневич Т.В., Ильина Е.Н., Щеголев А.И. Микробиологическая и молекулярно-генетическая характеристика коагулазонегативных стафилококков, выделенных у новорожденных отделения реанимации и интенсивной терапии.«Антибиотики и химиотерапия», 2013, 58; 3-4, 26 – 33
  19. Ilina EN, Shitikov EA, Ikryannikova LN, Alekseev DG, Kamashev DE, Malakhova MV, Parfenova TV, Afanas’ev MV, Ischenko DS, Bazaleev NA, Smirnova TG, Larionova EE, Chernousova LN, Beletsky AV, Mardanov AV, Ravin NV, Skryabin KG, Govorun VM. Comparative Genomic Analysis of Mycobacterium tuberculosis Drug Resistant Strains from Russia. PLoS ONE, 2013, 8(2): e56577. doi:10.1371/journal.pone.0056577
  20. Ikryannikova LN, Filimonova AV, Malakhova MV, Savinova T, Filimonova O, Ilina EN, Dubovickaya VA, Sidorenko SV, Govorun VM. Discrimination between pneumoniae and S. mitis based on sorting of their MALDI mass spectra. Clin Microbiol Infect. 2013 Nov; 19(11):1066-71. doi: 10.1111/1469-0691
  21. Kushnir AV, Ilina EN, Malakhova MV, Priputnevich TV, Filipenko ML. Multiple-locus variable number tandem repeat analysis of Neisseria gonorrhoeaeisolates in Russia. Infect Genet Evol. 2012 Dec 19; 14C:8. doi: Infect Genet Evol. 2013 Mar; 14:8-14. doi: 10.1016/j.meegid.2012.11.020
  22. Корниенко М.А., Ильина Е.Н., Боровская А.Д., Эдельштейн M.В., Сухорукова M.В., Кострцева М., Говорун В.М. Прямое бактериальное профилирование посредством MALDI масс-спектрометрии как метод быстрой классификации штаммов Staphylococcus aureus. Биомедицинская химия, 2012. Т. 58 N 5.-С.501-513.
  23. Shitikov E1, Ilina E, Chernousova L, Borovskaya A, Rukin I, Afanas’ev M, Smirnova T, Vorobyeva A, Larionova E, Andreevskaya S, Kostrzewa M, Govorun V. Mass spectrometry based methods for the discrimination and typing of mycobacteria. Infect Genet Evol. 2012 Jun; 12(4):838-45. doi: 10.1016/j.meegid.2011.12.013.
  24. Shevchenko OV, Mudrak DY, Skleenova EY, Kozyreva VK, Ilina EN, Ikryannikova LN, Alexandrova IA, Sidorenko SV, Edelstein MV. First detection of VIM-4 metallo-β-lactamase-producing Escherichia coli in Russia. Clin Microbiol Infect. 2012 Jul; 18(7):E214-7. doi: 10.1111/j.1469-0691.2012.03827.x. Epub 2012 Apr 4.
  25. Zubritskiĭ AV, Il’ina EN, Strel’chenko SA, Malakhova MV, Lenev SV, Skliarov OD, Panin AN, Govorun VM. Investigation of molecular mechanisms of aminoglycoside resistance in Salmonella. Antibiot Khimioter. 2011; 56(9-10):7-12. (In Russian).
  26. Ikryannikova LN, Lapin KN, Malakhova MV, Filimonova AV, Ilina EN, Dubovickaya VA, Sidorenko SV, Govorun VM. Misidentification of alpha-hemolytic streptococci by routine tests in clinical practice. Infect Genet Evol. 2011 Oct; 11(7):1709-15.
  27. Afanas’ev MV., Ikryannikova LN., Il’ina EN., Kuz’min AV., Larionova EE., Smirnova TG., Chernousova LN. and Govorun VM. Molecular typing of Mycobacterium tuberculosis circulated in Moscow, Russian Federation. Eur J Clin Microbiol Infect Dis. 2011 Feb; 30(2):181-91. doi: 10.1007/s10096-010-1067-z.
  28. Боровская А. Д., Ильина Е. Н., Савинова Т. А., Сидоренко С. В., Грудинина С. А., Говорун В. М. Дифференцировка α-гемолитических стрептококков прямым масс-спектрометрическим профилированием. Биоорганическая химия, 2011, том 37, № 1, с. 61–69
  29. Ilina EN1, Borovskaya AD, Serebryakova MV, Chelysheva VV, Momynaliev KT, Maier T, Kostrzewa M, Govorun VM. Application of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for the study of Helicobacter pylori. Rapid Commun Mass Spectrom. 2010 Feb; 24(3):328-34. doi: 10.1002/rcm.4394.
  30. Афанасьев М.В., Каракашев С.В., Ильина Е.Н., Салем А.-С.-А.-М. , Сидоренко С.В. и Говорун В.М. Молекулярно-генетическая характеристика метициллин-устойчивых штаммов Staphylococcusaureus, выделенных в стационарах г. Москвы. Журнал «Молекулярная генетика, микробиология и вирусология» 2010, № 2, стр.20-24
  31. Ikryannikova LN., Shkarupeta MM., Shitikov EA., Il’ina EN., Govorun VM. Comparative evaluation of new typing schemes for urogenital Chlamydia trachomatis isolates. FEMS Immunol Med Microbiol. 2010, Jul 1; 59(2):188-96. doi: 10.1111/j.1574-695X.2010.00678.x
  32. Савинова Т.А., Ильина Е.Н., Сидоренко С.В. Масс-спектрометрический анализ генетических маркеров резистентности pneumoniae к бета-лактамным антибиотикам. Журнал «Молекулярная генетика, микробиология и вирусология» 2010, № 3
  33. Ilina EN, Oparina NY, Shitikov EA, Borovskaya AD, Govorun VM. Molecular surveillance of clinical Neisseria gonorrhoeae isolates in Russia. J of Clinical Microbiology, 2010 Oct; 48(10):3681-9
  34. Афанасьев М.В., Боровская А.Д., Ильина Е.Н., Смирнова Т.Г., Ларионова Е.Е., Кузьмин А.В., Андреевская С.Н., Черноусова Л.Н., Говорун В.М. Выявление мутаций в 306 кодоне embB гена для молекулярно-генетической характеристики клинических штаммов Mycobacterium tuberculosis. Пробл. тубер. болезн. легких. — 2009. — № 5. — C. 48 — 53.
  35. Малахова М.В., Ильина Е.Н., Говорун В.М., Шутько С.А., Дудина К.Р., Знойко О.О., Климова Е.А., Ющук Н.Д. Масс-спектрометрическое генотипирование вируса гепатита В. Бюлл. экспер. биол. мед. – 2009. – Т. 147. – № 2. – С. 181 — 187.
  36. Ильина Е.Н., Говорун В.М. Масс-спектрометрия нуклеиновых кислот в молекулярной медицине. Биоорганическая химия. – 2009. – Т. 35. – №. 2. – C. 149 — 164.
  37. Владимиров Г.Н., Кононихин А.С., Ильина Е.Н., Говорун В.М., Николаев Е.Н. Точное измерение масс продуктов полимеразно-цепной реакции как метод генотипирования. Труды МФТИ. – 2009. – Т. 1. — № 1. – C. 36 – 40.
  38. Ilina EN, Borovskaya AD, Malakhova MM, Vereshchagin VA, Kubanova AA, Kruglov AN, Svistunova TS, Gazarian AO, Maier T, Kostrzewa M, Govorun VM. Direct bacterial profiling by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry for identification of pathogenicNeisseria. J Mol Diagn. 2009 11(1):75-86. doi: 10.2353/jmoldx.
  39. Атрошкина М.Е., Ильина Е.Н., Плахова К.И., Гомберг М.А., Кубанова А.А., Говорун В.М. Разработка ДНК- биочипа для исследования микробных сообществ. Молекулярная медицина. — 2009.- 3. — С.23 -31.
  40. Mellmann A, Bimet F, Bizet C, Borovskaya AD, Drake RR, Eigner U, Fahr AM, He Y, Ilina EN, Kostrzewa M, Maier T, Mancinelli L, Moussaoui W, Prévost G, Putignani L, Seachord CL, Tang YW, Harmsen D. High interlaboratory reproducibility of matrix-assisted laser desorption ionization-time of flight mass spectrometry-based species identification of nonfermenting bacteria. J Clin Microbiol. 2009 Nov; V. 47, N. 11, P. 3732-3734. doi: 10.1128/JCM.00921-09
  41. Ilina EN1, Vereshchagin VA, Borovskaya AD, Malakhova MV, Sidorenko SV, Al-Khafaji NC, Kubanova AA, Govorun VM. Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains. Antimicrobial Agents And Chemotherapy, 2008 Jun; 52(6):2175-82. doi: 10.1128/AAC.01420-07
  42. Ikryannikova LN, Shitikov EA, Zhivankova DG, Il’ina EN, Edelstein MV, Govorun VM. A MALDI TOF MS-based minisequencing method for rapid detection of TEM-type extended-spectrum beta-lactamases in clinical strains of Enterobacteriaceae. J Microbiol Methods. 2008 Dec; 75(3):385-91. doi: 10.1016/j.mimet.2008.07.005.
  43. Reinert RR, Filimonova OY, Al-Lahham A, Grudinina SA, Ilina EN, Weigel LM, Sidorenko SV. Mechanisms of macrolide resistance among Streptococcus pneumoniae isolates from Russia. Antimicrob Agents Chemother. 2008 Jun; 52(6):2260-2. doi: 10.1128/AAC.01270-07.
  44. Ющук Н.Д., Знойко О.О., Климова Е.А., Дудина К.Р., Кареткина Г.Н., Ильина Е.Н., Максимова С.Л. Генетическая изменчивость вирусов гепатита человека и ее клиническое значение. Москва, 2007 год.
  45. Боровская А.Д., Малахова М.В., Верещагин В.А., Ильина Е.Н., Говорун В.М., Припутневич Т.В., Аль-Хафаджи Н., Кубанова А.А. Анализ вклада молекулярных механизмов в формирование устойчивости гонококка к тетрациклину. Журнал «Бюллетень экспериментальной биологии и медицины», 2007, приложение 2, стр. 61 — 66.
  46. Afanas’ev MV, Ikryannikova LN, Il’ina EN, Sidorenko SV, Kuz’min AV, Larionova EE, Smirnova TG, Chernousova LN, Kamaev EY, Skorniakov SN, Kinsht VN, Cherednichenko AG, Govorun VM. Molecular characteristics of rifampicin and isoniazid-resistant Mycobacterium tuberculosis isolates from the Russian Federation. J Antimicrob Chemother. 2007; 59(6):1057-64.
  47. Малахова М.В., Верещагин В.А., Ильина Е.Н., Говорун В.М., Филимонова О.Ю., Грудинина С.А., Сидоренко С.В. Применение метода MALDI-TоF масс-спектрометрии для анализа генетически детерминированной устойчивости pneumoniae к фторхинолонам. Антибиот. Химиотер. – 2007.- Т. 52. – № 1 — 2. – С. 10 – 17.
  48. Мудрак Д.Е., Икрянникова Л.Н., Сидоренко С.В., Ильина Е.Н. Изучение распространенности и молекулярных механизмов антибактериальной резистентности у грамотрицательных возбудителей нозокомиальных инфекций в стационарах Москвы и Перми. // Антибиот. химиотер. — 2007.- Т. 52. – № 7 — 8. – С. 10-16.
  49. Ильина Е.Н., Малахова М.В., Верещагин В.А., Говорун В.М., Припутневич Т.В., Кубанова А.А. Прямая оценка параметров лекарственной устойчивости гонококка/ Журнал «Бюллетень экспериментальной биологии и медицины», 2007 г., Том 144, № 8, 194-197.
  50. Ikryannikova LN, Afanas’ev MV, Akopian TA, Il’ina EN, Kuz’min AV, Larionova EE, Smirnova TG, Chernousova LN, Govorun VM. Mass-spectrometry based minisequencing method for the rapid detection of drug resistance in Mycobacterium tuberculosis. J Microbiol Methods. 2007, 70(3):395-405.
  51. Афанасьев М.В., Икрянникова Л.Н., Ильина Е.Н., Смирнова Т.Г., Ларионова Е.Е., Кузьмин А.В., Черноусова Л.Н., Камаев Е.Ю., Скорняков С.Н., Киншт В.Н., Чередниченко А.Г., Говорун В.М. Применение минисеквенирования с последующей MALDI-TOF масс-спектрометрией для анализа развития устойчивости к рифампицину и изониазиду штаммов Mycobacterium tuberculosis, циркулирующих в Российской Федерации. Журнал «Проблемы туберкулеза и болезней легких». 2007; № 7, стр. 37-42.
  52. Плахова К.И., Гомберг М.А., Атрошкина M.E., Ильина Е.Н., Говорун В.М. Идентификация микробного состава выделений из влагалища методами генодиагностики. Вест. дермат. венерол. – 2007. – № 6. – C. 9 — 13.
  53. Плахова К.И., Гомберг М.А., Атрошкина М.Е., Ильина Е.Н., Говорун В.М. Роль Atopobium vaginae при рецидивировании бактериального вагиноза// Вест. дермат. венерол. — 2007. – № 5. – C. 10 — 13.
  54. Малахова М.В., Верещагин В.А., Ильина Е.Н., Говорун В.М., Зубков М.М., Припутневич Т.В., Кисина В.И., Кубанова А.А. Анализ генетических маркеров резистентности gonorrhoeae к лактамным антибиотикам. // Бюлл. экспер. биол. мед. – 2006. – Т. 141. – № 5. – С. 549 — 554.
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