Laboratory of artificial antibodies

People

People

Galina E. Pozmogova

Founder:

Galina E. Pozmogova

Prof., DSc

состав лаборатории искусственного антителогенеза
Acting head

Anna Varizhuk

Senior researchers

Igor Smirnov, Ph.D.
Yulia Kirillova, Ph.D.
Vyacheslav Severov, Ph.D.
Vladimir Tsvetkov, Ph.D.

Senior engineer

Vladimir Karpov

Researcher

Tatjana Vedekhina, Ph.D.

Junior researchers and PhD students

Iuila Pavlova
Sofia Kharanzhevskaya
Julia Svetlova
Natalia Petrunina

Scientific interests and research areas

Scientific interests and research areas

Our group has a long-standing interest in DNA/RNA aptamers as functional analogs of antibodies.

Current research areas include the dynamics and biological roles of non-canonical nucleic acid structures (ncDNA), such as G-quadruplexes (G4s) or i-motifs (iMs).

To clarify the interplay between ncDNA formation, chromatin packaging, and gene expression regulation, we investigate G4/iM-protein interactions and optimize ligands/light-up probes for selective targeting/visualization of genomic ncDNA. Using in silico modeling and biophysical methods, we study the recruitment of transcription factors or chromatin remodelers to G4 sites in the human genome.

Other ongoing projects include the design of selective small-molecule G4 binders and the development of iM-based tools for monitoring intracellular pH changes.

Collaborators

Collaborators

  • Lomonosov Moscow State University,
  • Lomonosov Moscow State University of Fine Chemical Technology,
  • Engelhardt Institute of Molecular Biology,
  • D. Mendeleev University of Chemical Technology of Russia

List of selected publications

List of selected publications

Contacts

Phones:
+7 (499) 246-4570,
+7 (499) 246-9646

E-mail:
annavarizhuk@rcpcm.org