Александр Викторович Тяхт

Александр Тяхт
Александр Тяхт

e-mail: at [at] niifhm [dot] ru

Occupation:
Associate scientist (Research Institute of Physico-Chemical Medicine, Laboratory of Bioinformatics).

Education:
2005 Master degree – Moscow State University, Faculty of Computational Mathematics and Cybernetics (Nonlinear dynamical systems and Control processes department)

Skills and interests:
Bioinformatics, statistical data analysis and visualization, pattern recognition, programming, chaotic dynamical systems.

Текущие проекты
Russian Metagenome Project: country-wide study of human gut microbiota in health and disease.
Metabolic and ecological modeling of complex microbial communities.
Genomic analysis of socially important bacterial species.
Organization of high-throughput workflow for genomic data analysis on a compute cluster.
Genetic profiling of few human genomes: clinical associations, risks assessment.
Transcriptomic analysis of human cell lines.
Публикации
Tyakht AV, Kostryukova ES, Popenko AS, Belenikin MS, Pavlenko AS, Larin AK, Karpova IY, Selezneva OV, Semashko TA, Ospanova EA, Babenko VV, Maev IV, Cheremushkin SV, Kucheryavy YA, Shcherbakov PL, Grinevich VB, Efimov OI, Sas EI, Abdulkhakov RA, Abdulkhakov SA, Lyalyukova EA, Livzan EA, Vlassov VV, Sagdeev RZ, Tsukanov VV, Osipenko MF, Kozlova IV, Tkachev AV, Sergienko VI, Alexeev DG., Govorun V.M., Human gut microbiota compositions found across urban and rural populations of Russia. Nature Communications 2013, doi:10.1038/ncomms3469

Zgoda, Victor G., Arthur T. Kopylov, Olga V. Tikhonova, Alexander A. Moisa, Nadezhda V. Pyndyk, Tatyana E. Farafonova, Svetlana E. Novikova, Andrey V. Lisitsa, Elena A. Ponomarenko, Ekaterina V. Poverennaya, Sergey P. Radko, Svetlana A. Khmeleva, Leonid K. Kurbatov, Aleksey D. Filimonov, Nadezhda A. Bogolyubova, Ekaterina V. Ilgisonis, Aleksey L. Chernobrovkin, Alexis S. Ivanov, Alexei E. Medvedev, Yury V. Mezentsev, Sergei A. Moshkovskii, Stanislav N. Naryzhny, Elena N. Ilina, Elena S. Kostryukova, Dmitry G. Alexeev, Alexander V. Tyakht, Vadim M. Govorun, and Alexander I. Archakov. "Chromosome 18 Transcriptome Profiling and Targeted Proteome Mapping in Depleted Plasma, Liver Tissue and HepG2 Cells." Journal of proteome research 12, no. 1 (2012): 123-134.

Д.Г. Алексеев, Е.С. Кострюкова, А.С. Попенко, И.В. Русаловский, А.В. Тяхт. Потенциальные возможности использования распределенных вычислительных систем при решении концептуальных проблем построения информационных комплексов обработки данных высокопроизводительного геномного секвенирования и глубокого протеомного профилирования. Информатизация и связь, 8 (2012)

Alexander V. Tyakht, Anna S. Popenko, Maxim S. Belenikin, Ilya A. Altukhov, Alexander V. Pavlenko, Elena S. Kostryukova, Oksana V. Selezneva, Andrei K. Larin, Irina Y. Karpova, Dmitry G. Alexeev. MALINA: a web service for visual analytics of human gut microbiota whole-genome metagenomic reads. Source Code for Biology and Medicine 2012, 7:13

Altukhov A, Ischenko D, Alexeev D, Bazaleev N, Uvarovskiy A, Tyakht A. Web-application for comparative structural and functional analysis of prokaryotic genomes sequencing data. Proceedings of Moscow Conference on Computational Molecular Biology Moscow, Russia July 21–24, 2011, P.36

Участия в конференциях
Tyakht A.V., Popenko A.S., Zelenin A.S., Kovarsky B.A., Alexeev D.G., Karpova I.Y., Larin A.K., Solopova G.G., Dzhandarova D.T., Roumiantsev S.A., Kostryukova E.S. Temporal evolution of gut microbiota during chemotherapy in acute leukemia pediatric patients. International Human Microbiome Congress (IHMC), Hangzhou, 2013.

Peskov, K., Kosinsky, Y., Popenko, A., Tyakht, A., & Alexeev, D. Mechanistic modeling approach relating human gut microbial community to physiologically-relevant biomarkers. In SYSPATHO WORKSHOP SYSTEMS BIOLOGY AND MEDICINE (p. 53), 2012.

Метагеномный анализ микробиоты населения РФ. Тяхт А.В., Попенко А.С., Беленикин М.С., Павленко А.В., Алексеев Д.Г. III международная научно-практическая конференция "Постгеномные методы анализа в биологии, лабораторной и клинической медицине", Казань, 2012.

Tyakht A, Popenko A, Belenikin M, Altukhov I, Alexeev D. Examining composition of Russian human gut microbiota by assessing relative abundance of functional and taxonomical units. International Human Microbiome Congress (IHMC-2012), Paris, 2012.

Popenko A, Tyakht A, Altukhov I, Alexeev D. MALINA – a Web-service for human gut microbiota whole-genome metagenomic reads analysis. International Human Microbiome Congress (IHMC-2012), Paris, 2012.

Прослушанные курсы
"Genomic Data Analysis" course by Cold Spring Harbor Laboratory, Moscow, 2012

"Bioinformatics Tools and Innovation through Collaboration", National Institute of Allergy and Infectious Diseases & International Science and Technology Center, Moscow, 2011

SOLiD Bioscope training, Darmstadt, 2010